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To generate sufficient quantities of ROS and RNS quickly, these cells require rapid flux through the PPP to produce sufficient amounts of NADPH to enable superoxide formation from oxygen by the action of NADPH oxidase (NOX), and nitric oxide (NO) formation from arginine by inducible nitric oxide synthase (iNOS) ( Figure 1A-2 )

emphasize the need for clarity in indications, protocol optimization, and pinpointing the patient demographics most likely to benefit [60]

The bag runs by gravity or pump over 30 to 90 minutes, depending on volume and ingredients

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